This is going to be easy.
#1: ARM gives Intel/AMD/VIA a run for its money
Yes, lowly RISC processors are coming in huge densities, all using much less power. Seems counter-intuitive, but there’ll be multiple OS changes to accommodate the density possibilities, mostly in interesting server combinations.
#2: Social Sickness
Twitter, Facebook, G+, all interesting. A unified user interface that just does it will become popular, and will separate the truly social from the casual. The client piece will be fought tooth and nail because it disrupts the business models of the social site vendors.
#3: The Great Server Makers Will Fall and NOCs Will Change Forever (for the better)
Servers aren’t what they used to be. High density servers will steal the market. NOCs will start to look like clouds, and many skies of clouds. Traditional server makers will have some problems getting to market and learning how to make margins based on differing densities.
#4: Client Hardware Will Become: Anything
I want my (fill in this blank) to work on the darn network. Make it so. Desktop hardware doesn’t go away, there is no death of anything. Instead, accessibility will become the huge challenge for large organizations, who will become driven by user pressures. This will lead to
#5: Security Rethought
Unified security will become the norm with (gasp!) interoperability. Lacking that, we have chaos. Maybe the government will wake up, too, but I doubt it.
And finally, Obama wins, and someone will owe me yet another beer to pay me off.